GLP-1 & Skin Laxity: What You Need to Know and How to Support the Skin with Pro NAD

The rise of GLP-1 receptor agonists like semaglutide and tirzepatide has brought a new dimension to aesthetic and wellness conversations. Originally designed to support blood sugar control and weight loss, these medications are now widely used for their metabolic benefits. But as Professional Skin Therapists, we’re starting to see the visible side effects and they're showing up in our treatment rooms.

Let’s take a closer look at how GLP-1 medications may contribute to skin laxity and muscle loss, and how Pro NAD can support the skin from the inside out.

What Are GLP-1 Medications and Why Are They Causing Skin Concerns?

GLP-1 receptor agonists work by mimicking a hormone that slows digestion and promotes satiety, helping with weight loss. However, rapid fat reduction can lead to:

  • Loss of volume

  • Skin laxity or sagging

  • Visible changes in muscle tone

This is sometimes referred to as “Ozempic face” in popular media though the underlying changes are physiological, not cosmetic. The muscle mass loss associated with these medications, combined with collagen decline, can accelerate visible signs of aging.

The Role of NAD+ in Skin + Muscle Health

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in cellular energy, mitochondrial function, and DNA repair. As we age, NAD+ levels naturally decline, and this drop is further accelerated by metabolic stress, inflammation, and muscle loss.

That’s where Pro NAD comes in.

Pro NAD: Cellular Support for the Modern Skin Client

Pro NAD is formulated to support NAD+ production and energy metabolism, helping skin cells maintain optimal performance during times of stress or change including significant weight loss or muscle atrophy.

Here’s how it helps:

  • Supports collagen and elastin synthesis to address visible laxity

  • Energizes fibroblasts for stronger structural integrity

  • Helps buffer oxidative stress and inflammation that can accelerate aging

  • May support muscle cell recovery and improve overall skin tone and density

What This Means for Professional Skin Therapists

Clients on GLP-1 medications may be seeing impressive changes in body composition but they’ll need targeted skin support to maintain their healthiest skin. Incorporating topical Pro NAD technology, along with skin-firming modalities like microneedling, muscle stimulation, or sculpting massage, can offer real benefits.

Ask these questions during consultation:

  • Have you started any new medications recently?

  • Have you noticed changes in facial shape, firmness, or volume?

  • Would you like support in maintaining skin tone as your body changes?

When we connect skin physiology with medical trends, we elevate our role from service provider to trusted skin health advisor.

The Future Is Personalized, Proactive Skin Support

As the industry shifts toward longevity and metabolic health, our approach to skin care must evolve too. Tools like Pro NAD empower us to meet the moment with science-backed, cell-supporting strategies helping clients feel good in their skin at every stage of transformation.

The International Dermal Institute has developed a Dynamic Skin Sculptor for Dermalogica for targeted use on the neck and body to combat skin laxity.

Have you seen rapid weight loss induced skin laxity in the treatment room? What are your top ingredient and technique tips? We’d love to know, share in the comments below.